Supplementary Figure 1: Mutations found in the TK domain of the HyTK gene in various FMR1-(CGG)n-HyTK cassettes.
From: Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system
DNA bases in the TK domain of the wild-type HyTK gene that underwent mutagenesis are shown in bold. Mutations found in the cassettes with (CGG)0, (CGG)53, and (CGG)153 repeats are shown in green, blue, and red, respectively; mutations found in the cassette with (CGG)153 repeats upon treatment with Pold3 siRNA are shown in orange; and G7 and C6 mutation hotspots are highlighted in yellow. V, insertion; Δ, deletion; D, duplication; FV, insertion to frameshift; FΔ, deletion to frameshift; X, complex mutation; AT and TT, tandem base substitutions.
