Supplementary Fig. 6: Intracellular intra-bundle polar interactions.
From: Structural basis for the delivery of activated sialic acid into Golgi for sialyation
Cartoon representation showing the residues which by polar interactions stabilize the two transport bundles (colored cyan and wheat, respectively) in the outward-facing conformation. CSTZM E181 is equivalent to hCST E196, which when mutated to lysine (E196K) causes a congenital disorder of glycosylation as it abolishes CST transport activity (Fig. 3d).
