Supplementary Fig. 5: Cryo-EM reconstructions of PF846-stalled PCSK9 and USO1 RNCs. | Nature Structural & Molecular Biology

Supplementary Fig. 5: Cryo-EM reconstructions of PF846-stalled PCSK9 and USO1 RNCs.

From: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

Supplementary Fig. 5: Cryo-EM reconstructions of PF846-stalled PCSK9 and USO1 RNCs.

a, PCSK9-RNC in the rotated state with A/P and P/E tRNA, with 40S subunit (light blue), 60S subunit (grey), A/P site tRNA (green), P/E site tRNA (magenta) stalled PCSK9 nascent chain (blue) and PF846 (dark green) shown. b, PCSK9-RNC in the rotated state with A/A tRNA (orange) and P/E tRNA (magenta). c, Non-rotated state of the PCSK9-RNC stalled by PF846, with P/P tRNA (dark orange). d, USO1-RNC in the rotated state with A/P and P/E tRNA. Color coding as in panel (a), but with the NC in cyan.

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