Supplementary Figure 7: The dagger-shaped fold and the hydrogen bond enriched hairpin structure in SegA-slow.
From: Cryo-EM structures of four polymorphic TDP-43 amyloid cores
a, SegA-slow is shown in cartoon. The dagger-shaped fold (residue 312–346, upper panel) and the hydrogen bond enriched hairpin (residue 342–360, bottom panel) is colored pink, and the rest of the residues are colored gray. Note that both the dagger-shaped fold and the hydrogen bond enriched hairpin are individually compatible with full-length TDP-43 with free N- and C-terminals. b, Top view of hydrogen bond enriched hairpin structure in SegA-slow (left) and (right) side views of residues involved in hydrogen bond network.
