Supplementary Figure 10: Space limitation of Q303W in the R-shaped fold.
From: Cryo-EM structures of four polymorphic TDP-43 amyloid cores
Gln303 in three continuous layers of the inner chain of the R-shaped fold was computationally mutated to tryptophan with all possible rotamers adopted. Steric clash was probed with COOT and displayed as red dots. Notice that the un-mutated Gln303 show no steric clash whereas all rotamers of Try303 show steric clash, indicating that Q303W is not compatible with the R-shaped fold.
