Supplementary Figure 5: Detailed analysis of the dagger-shaped fold.
From: Cryo-EM structures of four polymorphic TDP-43 amyloid cores
(Upper panels) Three polymorphs of SegA are shown in cartoon and colored according to the color key. The core region of the dagger-shaped fold (residue 320–334) is colored red. (Bottom panels) Pairwise superposition of the dagger-shaped fold. (Left and middle) SegA-sym vs. SegA-asym short chain aligned at stem and dagger, respectively; (right) SegA-sym vs. SegA-slow. (Detailed alignment parameters are listed in Supplementary Table 2).
