Supplementary Figure 7: Alternative Rosetta models at -100 mV using different weights for experimentally-determined distance constraints.
From: The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization
Structure of 11 models varying the weights of experimentally-determined distance constraints from 50% to 200% of that used for the model in Fig. 5 (weight of 15, also see Methods). The green-colored S4 helix is the model shown in Fig. 5. The S4 helices in the other 10 models are shown in different colors.
