Extended Data Fig. 5: SRSF1 motif number is increased around the differential splicing sites of the selected essential candidate genes.
From: PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
a, Median absolute numbers of SRSF1 motifs near all the splicing sites that do not change upon PRMT5 depletion and near the splicing sites that change upon PRMT5 KD in the selected essential candidate genes (FDPS, PDCD2, PNISR, PNKP, POLD1, POLD2, PPP1R7) (fixed thresholding). Boxplot summary: outliers (diamonds), minimum (lower whisker), first quartile (lower bound of box), median (horizontal line inside box), third quartile (upper bound of box), interquartile range (box), and maximum (upper whisker). b, Table summary of the identified SRSF1 binding sites in all the splicing events that change upon PRMT5 KD in the FDPS, PDCD2, PNISR, PNKP, POLD1, POLD2, PPP1R7 genes.
