Supplementary Figure 5: Docking of the MYC-TBP anchor motif to TBP.
From: Multiple direct interactions of TBP with the MYC oncoprotein
a, Sequence of docked MYC-TBP anchor motif (coloured as in Fig. 4b). b,c,d: Evaluation parameters of the top 10 predicted models: b, Rosetta reweighted energy score. c, The DDDE hydrogen bond index denotes the total number of side chain hydrogen bonds from D118, D120, D121 and E122 to TBP. d, The MYC-F(115,124) burial index denotes the degree of side chain burial into TBP of the most buried aromatic in the MYC-TBP anchor motif in the respective models (MYC-F114 or MYC-F124). e,f,g: Structural comparison of the TBP-docked MYC model (coloured as in Fig. 4e) with similar TBP anchor motifs bound to TBP: e, BRF1 (PDB: 1NGM), f, BRF2 (PDB: 5N9G), g, TAF1(TAND2) (PDB: 4B0A), coloured blue where lighter colouring indicates positioning of negatively charged residues, buried aromatics are shown as sticks (purple), and N and/or C-termini are indicated.
