Extended Data Fig. 5: Comparison of fusion peptide conformations in Env structures.
From: Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody
The fusion peptide is orange in the conformation A protomer, cyan in the conformation B protomer (from the E51-sCD4-BG505 complex structures reported here), teal in a partially-open 17b-sCD4-BG505-8ANC195 complex (PDB 6CM3), and pale cyan in a fully-open 17b-sCD4-B41 complex (PDB 5VN3). Fusion peptides from Env trimers in a closed, prefusion conformation are color coded as shown for their PDB IDs. References for structures are listed in Supplementary Table 2.
