Extended Data Fig. 7: Cryo-EM density of ACLY ligands.
From: Molecular basis for acetyl-CoA production by ATP-citrate lyase
a, CoA in ACLY–CoA–citrate. b, Acetyl-CoA in ACLY–OAA–acetyl-CoA. c, Phosphor-citryl-CoA in ACLY-E599Q–ATP-citrate-CoA. d, Superposition of Acetyl-CoA and Phosphor-citryl-CoA showing movement of F537 as a function of bound intermediate/product.
