Extended Data Fig. 6: Comparison of BRAF:14-3-3 complex from this study (x-ray) with recently published BRAF:14-3-3 complexes (CryoEM).
From: Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
a, Crystal structure of BRAF dimer (blue) bound to 14-3-3 (yellow, orange) reported in this work, aligned by 14-3-3 dimer onto the BRAF:14-3-3 structure (left) reported in PDB: 6UAN, and (right) the BRAF:MEK1:14-3-3 structure reported by in PDB:6Q0J (BRAF-14-3-3 in grey, MEK1 in pink). b, Overlay of structures aligned by BRAF dimer, with structure pairs and coloring as described in a.
