Extended Data Fig. 3: Interactions of MlaE to the peripasmic MlaD and the cytoplasmic MlaF.
From: Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB
a, Cartoon representation of PE-bound MlaFEDB complex. The colour scheme is the same as the Fig. 2. Each MlaE is surrounded by three TM segments from three adjacent MlaD subunits. b, MlaE interacts with the periplasmic domain of MlaD through the periplasmic loop 1 and 2. The interacting residues are labelled. c, The coupling helix residues of one MlaE unit interact with residues located at the groove of one MlaF unit. d, Two MlaD TM segments interact with the elbow helix of MlaE. e, The third MlaD TM segment interacts with TM1 and TM3 of MlaE.
