Extended Data Fig. 7: Comparison of LRR-CT, juxtamembrane, and TM regions from different members of TLRs.
From: Cryo-EM structures of Toll-like receptors in complex with UNC93B1
a Sequence alignment of LRR-CT, juxtamembrane, and TM regions from different members of TLRs. The conserved Phe and His residues among TLR3, TLR7, TLR8, TLR9 in the TM regions are indicated by red boxes. b Structural comparison of the LRR-CT, juxtamembrane, and TM regions of TLR3 from TLR3-UNC93B1 complex (this study, left), TLR7 from TLR7-UNC93B1 complex (this study, right). The two conserved disulfide bonds in LRR-CT are shown with sticks. c Electrostatic surface potential of the TLR7-UNC93B1 complex. Positive and negative electrostatic potentials are shown in blue and red, respectively.
