Extended Data Fig. 6: Structural comparison of SPTLC1–SPTLC2 heterodimer and bacterial spSPT homodimer shown from two different views.
From: Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex
Superimposition of the spSPT homodimer (PDB 2JG2) onto the SPTLC1–SPTLC2 heterodimer by Cα atoms. Except for the N-terminal extensions of SPTLC1 and SPTLC2, the two structures are highly similar: superimposition of the two structures over 586 aligned Cα atoms yielded an RMSD of 1.5 Å.
