Extended Data Fig. 3: EM maps of the SPT–ORMDL3 complex.
From: Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex
a, 3D EM reconstruction of the dimeric SPT–ORMDL3 complex, with density covering individual subunits colored same as in Fig. 1e. The detergent micelles, displayed at a low contour level, are shown as gray, semi-transparent surface to indicate the orientation of transmembrane domain. b,c, EM maps corresponding to representative segments (b) and active/nonfunctional sites (c) of the monomeric substrate−free SPT–ORMDL3 complex. Electron density maps contoured at 5 σ were prepared in PyMol.
