Extended Data Fig. 8: Connection of N-terminal density.
From: Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
Slices of 3D maps of the final reconstruction (left) and an earlier reconstruction with lower resolution (right). The positions that represent N-terminus of Model 1 and Model 2 are indicated by arrows. Note the weak density that represents the flexible N-terminus of hIAPP seems to connect to the position that represents the N-terminus of Model 2 in the final reconstruction (left); whereas in the lower resolution reconstruction (right), the weak density seems to connect to the position of N-terminus of Model 1.
