Extended Data Fig. 1: Cryo-EM data processing.
From: Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
a, Representative Krios micrograph of hIAPP fibrils. Blue and green arrows indicate two morphologies (twister and ribbon, respectively) identified by 2D classification. Notice they are not distinguishable by eye. b, Representative 2D classes and relative population of twister and ribbon morphologies. c, Representative 2D classes of twister with smaller box size particles showing the 4.8 Å β-sheet spacing, and the computed diffraction pattern from a representative 2D class. d, Central slice (left) and 2D projection (right) from the final reconstruction. Notice the 2D projection of final reconstruction is consistent with 2D classification. e-f, FSC curves between two half-maps (e) and the cryo-EM reconstruction and refined atomic model (f). Data for graphs in e and f are available as source data.
