Extended Data Fig. 2: Potential domain swapping of hIAPP models.
From: Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
Domain swapped versions of both Model 1 and Model 2 were built to test the possibility of domain swapping. In the swapped models, the residues between the N-terminus and Gly24 from one protofilament were connected to the residues between Ala25 and the C-terminus from the other protofilament of the un-swapped model. The density map with σ=3.0 is shown in blue mesh and that with σ=2.0 is shown in grey mesh. Notice that Gly24 in both swapped Model 1 and Model 2 is clearly out of the density, demonstrating that the domain swapping is not supported by our cryo-EM map.
