Extended Data Fig. 7: Conservation of active site residues throughout the TTLL family.
From: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes
a, Table showing conservation of critical active site residues among TTLL family members. Glutamylase initiases shown in grey, Glutamylase elongases in magenta; Glycylation initiases in green, Glycylation elongases, in blue. b, TTLL6 active site molecular surface color-coded according to conservation (as in (a)) illustrating the strong conservation in the donor glutamate binding site and variability of the acceptor glutamate binding site. c, Schematic of TTLL6 key active site interactions with the α-elongation analog.
