Extended Data Fig. 8: Estimation of secondary motif-dependent Rbfox events across neuronal cell types.
From: Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity
In a comparison of neuronal cell types with medium to highest Rbfox mRNA expression, exons likely to be regulated by Rbfox are significantly enriched in secondary motifs (P < .0084 Fisher’s exact test, ndown = 13; nup = 28). Of 864 alternative exons with increased splicing, 11% are primary, 26.4% primary and secondary, and 3.2% are 4+ secondary motif-associated. Exons with one to three secondary motif instances are also significantly enriched (P < 0.0012, Fisher’s exact test, ndown = 263; nup = 354). Stars indicate significant groupings.
