Fig. 3: Evaluation of SARS-CoV-2 2P DS S antigenicity. | Nature Structural & Molecular Biology

Fig. 3: Evaluation of SARS-CoV-2 2P DS S antigenicity.

From: Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation

Fig. 3: Evaluation of SARS-CoV-2 2P DS S antigenicity.

a–d, Binding to immobilized SARS-CoV-2 2P DS S (green) or SARS-CoV-2 2P S (black) of serially diluted concentrations of the human neutralizing antibodies S309 (a), S2H14 (c) and S304 (d) and the human ACE2 receptor fused to human Fc (b). e, Neutralization of SARS-CoV-2 S pseudovirus with human serum obtained from a patient with COVID-19. f, Binding of a serial dilution of the neutralizing convalescent serum shown in panel e to immobilized SARS-CoV-2 2P DS S (green) or SARS-CoV-2 2P S (black). Data are shown as mean and s.d. of n = 2 technical replicates; data are representative of two independent experiments. Data behind all graphs are available in Supplementary Data 1. A450, absorbance at 450 nm; ND, not determined.

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