Extended Data Fig. 4: The genomic features of enhancer-like ERVs in meiosis.
From: Endogenous retroviruses drive species-specific germline transcriptomes in mammals
a, Representative track views show H3K27ac ChIP-seq, ATAC-seq, RNA-seq, and A-MYB ChIP-seq signals on chromosome X. The red highlight indicates an enhancer-like ERV locus. b, Pie charts indicate the distributions of enhancer-like ERVs on autosomes and sex chromosome. c, Top: Bar chart depicts the numbers of enhancer-like ERVs on each chromosome. Bottom: Chromosome map shows the distribution of enhancer-like ERVs throughout the mouse genome. Values for H3K27ac enrichment represent log2 fold enrichment of H3K27ac signal relative to input. d, Box-and-whisker plots show relative H3K27ac enrichment at enhancer-like ERV loci on autosomes and sex chromosomes. Values: log2 fold enrichment of H3K27ac signal relative to input. Central bars represent medians, the boxes encompass 50% of the data points, and the error bars indicate 90% of the data points. We detected no statistical difference in H3K27ac enrichment at autosome enhancer-like ERVs vs. sex chromosome enhancer-like ERVs: P = 0.307, Mann-Whitney U test. e, Bar chart shows enhancer-like ERVs distribution across genomic entities (intergenic, intronic, etc.) in autosomes versus the sex chromosomes: P = 3.6 × 10-5, Chi-square test with Yates’s correction. f, The consensus sequence of RLTR10B, listed in the Dfam database, contains two A-MYB binding motifs (GGCAGTT).
