Extended Data Fig. 5: Formation of the dimer-of-dimer interface.
From: Structures of mouse DUOX1–DUOXA1 provide mechanistic insights into enzyme activation and regulation
a, b, Structural comparison of DUOX1 and DUOXA1 in heterodimeric and dimer-of-dimer states. c, Interaction between DUOX1 and DUOXA1. Left: interactions between DUOX1 and the N-terminal loop and glycan chain linked to N109 of DUOXA1. Right: cryo-EM density and cartoon of the glycan chain on N109. d, Interactions between transmembrane domains of DUOX1 and DUOXA1 mediated by a lipid molecule. Left: interaction details. Right: density of the lipid molecule. e, PHD-PHD interactions in the dimer-of-dimer configuration. Left: interactions between PHDs of DUOX1. Right: comparison between MPO dimers and PHD dimers of DUOX1.
