Extended Data Fig. 9: MALDI TOF/TOF analyses.
From: Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Top) Aβ1-42 in the presence of chaducanumab. Example of a MALDI TOF/TOF spectrum with direct spotting of samples collected at the half-time of aggregation of Aβ1-42 in the presence of chaducanumab. Middle and bottom) Aβ1-42 in the presence of m266. Example of a MALDI TOF-TOF spectra with HPLC separation before spotting for samples collected at the half-time of aggregation of Aβ1-42 in the presence of m266. In Fraction 9 there is so much 14N peptide that the signal from 15N is suppressed.
