Extended Data Fig. 10: Antibody binding analysis in solution.
From: Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
a) Diffusion of Alexa-647-Aβ(MC1-42) in the absence and presence of increasing concentration of isotype control antibody. b) Diffusion of Alexa-647-labeled isotype control antibody in the absence and presence of increasing concentrations of unlabelled Aβ1-42 fibrils. In both panels are shown the fraction of fluorescence appearing in the diffused half at the channel outlet as a function of total concentration of the non-labeled species. The solid lines are fitted straight lines. c) The same data as in Fig. 3c, e, f replotted with the ratio of fibril to antibody concentration on the X-axis. The fibril concentration is in monomer units. d) Examples of results of Bayesian analysis.
