Extended Data Fig. 4: Effects of the antibodies on the rate constants.
From: Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
The rate constant values relative to Aβ42 alone are shown as a function of the antibody concentration for the case that produced the best fit to the data for each antibody (see Fig. 1). For chaducanumab (a) we thus show the effect on the rate constant for secondary nucleation, k2, up to 125 nM antibody, and thereafter the effects in kn and k2. For m266 (b) we show the effect on the rate constant for primary nucleation, kn. For 3D6 (c) and chgantenerumab (d) we show the effect on the elongation rate constant, k+.
