Extended Data Fig. 4: Comparison of the SLD-FANCI interaction with the SUMO3-Thymine-DNA glycosylase (TDG) interaction. | Nature Structural & Molecular Biology

Extended Data Fig. 4: Comparison of the SLD-FANCI interaction with the SUMO3-Thymine-DNA glycosylase (TDG) interaction.

From: Structural basis of FANCD2 deubiquitination by USP1−UAF1

Extended Data Fig. 4: Comparison of the SLD-FANCI interaction with the SUMO3-Thymine-DNA glycosylase (TDG) interaction.

The SLD of UAF1 from the USP1-UAF1-FANCI-FANCD2Ub structure and SUMO3 of the SUMO3-Thymine-DNA glycosylase complex (PDB 2D07)63 were aligned. The N and C terminal sides of the FANCI loop are indicated, highlighting the anti-parallel arrangement with respect to the proximal β-strand of the SLD.

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