Extended Data Fig. 4: Isoproterenol occupancy in orthosteric binding pocket of β1-AR. | Nature Structural & Molecular Biology

Extended Data Fig. 4: Isoproterenol occupancy in orthosteric binding pocket of β1-AR.

From: Structural basis and mechanism of activation of two different families of G proteins by the same GPCR

Extended Data Fig. 4

(a,b) Side view (a) and oblique view (b) of activated β1-AR to highlight the location of the agonist isoproterenol bound in the orthosteric binding pocket at the extracellular side of the receptor. β1-AR is shown in cartoon in red and isoproterenol is shown in green. Experimental density carved around ligand shown at 13σ, supporting complete occupancy. (c) Close-up view of the orthosteric binding pocket with model docked into 8σ experimental density to highlight agonist coordination. Isoproterenol is colored in green and residues lining the binding pocket are in red.

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