Extended Data Fig. 7: Structural changes of G-proteins during the activation.

Separation of the Ras-like domains of Gi (a) and Gs (b) from Gβγ subunits in the complex of β1-AR–Gi (a) and β1-AR–Gs (b). Gβγ subunits are superimposed.

Separation of the Ras-like domains of Gi (a) and Gs (b) from Gβγ subunits in the complex of β1-AR–Gi (a) and β1-AR–Gs (b). Gβγ subunits are superimposed.