Extended Data Fig. 10: Structural comparisons of the β1-AR–Gi complex with other GPCR–Gi complexes. | Nature Structural & Molecular Biology

Extended Data Fig. 10: Structural comparisons of the β1-AR–Gi complex with other GPCR–Gi complexes.

From: Structural basis and mechanism of activation of two different families of G proteins by the same GPCR

Extended Data Fig. 10

(a) The structure of β1-AR–Gi1 (in green) is superimposed with rhodopsin–Gi1 (PDB 6CMO, in magenta), cannabinoid receptor 1–Gi1 (PDB 6N4B, in cyan), and mu-opioid receptor–Gi1 (PDB 6DDE, in yellow). (b) Comparisons of the Gαi1Gβγ trimer structures in the four complexes (superimposed by Gβ subunits). (c) Comparisons of the interactions between ICL2s of the receptors and the αN-helices of Gαi1. (d) Comparisons of the interactions between the α5-helices of Gαi1 and the receptors. (e) Structural comparison of the regions around G203 of Gαi1 in the four structures.

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