Extended Data Fig. 8: Variability in density for the Chd1 DNA-binding domain, exit DNA, and the bridge.
From: Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state
a, Overview of a filtered Chd1-nucleosome reconstruction where the DNA-binding domain is well-defined. b, Zoomed-in views showing different sub-classes obtained from the dataset, exhibiting variability in the exit DNA and the DNA-binding domain. c-f, Visualization of variability of the connection (‘bridge’) between the brace helix and the DNA-binding domain. c, Model of the nucleosome-bound Chd1. d, Model of the nucleosome-bound Chd1 model converted into a map, filtered to 10 Å. e, Separated unmodeled density (purple) from the 2.3 Å Coulomb potential density reconstruction as shown against the map from d. f, Unmodeled densities (various colors) from subsets obtained using focused classification, shown against the map from d.
