Extended Data Fig. 5: Pathogenic substitutions in the D10C domain affect clusters of highly conserved residues. | Nature Structural & Molecular Biology

Extended Data Fig. 5: Pathogenic substitutions in the D10C domain affect clusters of highly conserved residues.

From: Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

Extended Data Fig. 5

a-b, GP2 D10C residues corresponding to UMOD amino acids mutated in kidney disease patients (panel a, red) are largely clustered into two highly conserved protein regions (panel b). Sequence conservation is represented using a color spectrum ranging from green (lowest conservation) to violet (highest conservation). c-g, Alternative representation of the structural details shown in Fig. 1c–g, with residues colored by sequence conservation.

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