Extended Data Fig. 4: Pharmacological inhibition of mTOR kinase and PI3Kγ by Torin-2 and PIK-90.
From: Structural basis of phosphatidylinositol 3-kinase C2α function
(a,b) 2D structure and IC50 of Torin-2 (a) and PIK-90 (b) bound to PI3KC2α. (c) Binding pocket of mTOR in association with Torin-2 (pdb: 4JSX). W2239 from the hinge of mTOR kinase contributes a pi-pi interaction with Torin-2. (d) Binding pocket of PI3Kγ in complex with PIK-90 (pdb: 2CHX). The pyridine ring of PIK-90 binds to a deep cavity in the affinity pocket of PI3Kγ.
