Extended Data Fig. 3: Comparison of Rad24-RFC:9-1-1 with RFC-PCNA.
From: Mechanisms of loading and release of the 9-1-1 checkpoint clamp
a-b, Structures of Rad24-RFC:9-1-1 (a) and RFC-PCNA (b, PDB:1SXJ) colored by subunit with Rad24-RFC / RFC in surface depiction and 9-1-1 / PCNA in ribbon depiction. The channel formed between the AAA + , collar and A’ domains of Rad24 in a is highlighted by the dashed oval. c, Superposition of Rad24-RFC (colored by domain) with RFC (gray). The models are aligned by the collar domains. d, Superposition of Rad24-RFC subunits (colored by subunit) with RFC subunits (grey). The subunits are aligned by their collar domains. For Rad24 and Rfc1, the A’ domains are removed for clarity. e, Nucleotide-binding sites in the AAA + domains Rad24-RFC:9-1-1. Nucleotides and residues whose side chains coordinate the nucleotide are shown in sticks.
