Extended Data Fig. 9: Cryo-EM analysis of the IR-insulin WT complex at subsaturated insulin concentrations.
From: Synergistic activation of the insulin receptor via two distinct sites
a. Representative electron micrograph and 2D class averages of the IR-insulin WT complex at subsaturated insulin concentrations. Scale bar: 200 Å. This experiment was repeated for 3,635 times independently with similar results. b. Unsharpened cryo-EM maps colored by local resolution. c. The gold-standard Fourier Shell Correlation (FSC) curve for the cryo-EM map shown in Fig. 6a-d. d. Flowchart of cryo-EM data processing.
