Fig. 6: Substrate density in open TRiC.
From: Snapshots of actin and tubulin folding inside the TRiC chaperonin
a, Filtered 4.0-Å resolution reconstruction map of open TRiC in side (left) and top (right) views. b, Cartoon representation showing apical domains built into map, as well as intermediate and apical domains modeled by flexible fitting; same views as a. c, Side slice of open TRiC with substrate density in cyan. d, Slice of substrate density at low isosurface threshold, in the septum of open TRiC. e, Proposed mechanism of TRiC-mediated substrate folding based on this work. TRiC structures shown are from this study (steps 2, 4, 5, 5') or from PDB 5GW4 (step 1). PFD, prefoldin.
