Extended Data Fig. 8: CENP-N affects the folding of chromatin arrays.
From: CENP-N promotes the compaction of centromeric chromatin
a) Comparison between tetra-nucleosomes in a chromatin fiber with CENP-N, and of a canonical tetra-nucleosome. Analysis of the relative orientation of the nucleosomes, in analogy to DNA base pair analysis, is shown in the middle panel, with numbers for the CENP-N array in red, and tetranucleosome array in black. b) CryoEM analysis of crosslinked chromatin arrays without CENP-N, raw cryoEM image. Size bar is 100 nm c) 2D classification of CENP-N in complex with 12-167mer array. d) Low resolution 3D cryoEM map illustrates ladder-like arrangement of nucleosomes.
