Fig. 5: Model of how the cohesin acetylation cycle controls chromatin loop length. | Nature Structural & Molecular Biology

Fig. 5: Model of how the cohesin acetylation cycle controls chromatin loop length.

From: The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism

Fig. 5: Model of how the cohesin acetylation cycle controls chromatin loop length.The alternative text for this image may have been generated using AI.

a, Cohesin acetylation regulates the size of architectural stripes and loops. Our data support a model in which ESCO1 acetylates SMC3 to pause cohesin looping while HDAC8 deacetylates cohesin to promote further loop enlargement. b, Cohesin acetylation converts cohesin into a PDS5A-bound state. We propose that this PDS5A binding to cohesin could inactivate cohesin’s ATPase to pause the looping process. Deacetylation by HDAC8 could alleviate this brake to restart the looping reaction.

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