Extended Data Fig. 4: Snake plot of the amino acid sequence of APJR and sequence analysis of dimer interface (F23.52G3.21T3.22F3.23F3.24) with all 289 class A GPCRs.
From: Structural insight into apelin receptor-G protein stoichiometry
a, Residues that form the dimer interface are shown in green, residues that interact with cmpd644 are shown in red and residues that interact with the G protein are shown in blue or circled in red in dimer or monomer, respectively. b, Calculation of covered dimer interface area in APJR, mGlu5 (PDB ID: 6N51), GABAB (PDB ID: 6W2Y), CaSR (PDB ID: 7DTV), and class D GPCR Ste2 receptor (PDB ID: 7AD3). c, Sequence alignment of F23.52G3.21T3.22F3.23F3.24 within all 289 class A GPCRs, revealing that F23.52, G3.21 are highly conserved (45% and 62%, respectively), F3.23 and F3.24 are intermediately conserved (13% and 10%, respectively), and T3.22 is the least conserved (6.5%). The proportion of the aromatic group at each position of this sequence string (from position 23.52 to 3.24) is 45.7%, 1.3%, 9.7%, 19.7%, and 14.5%, respectively.
