Extended Data Fig. 3: Interactions between the MTase domain and ExoN domain.
From: High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development

The nsp14 MTase core, ExoN domain, and the hinge region are colored cyan, slate blue and orange, respectively (PDB:7N0D). ExoN stabilizes the MTase domain via polar and non-polar interactions with the hinge and N7-MTase core.