Extended Data Fig. 5: ITC analysis of nsp14/10 complex with SAM, SAH and SFG.
From: High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
ITC titration data for SAM (left), SAH (middle) and SFG (right) with the nsp14/nsp10 complex are shown. The equilibrium dissociation constants (KD) were derived from the resulting binding isotherms. The chemical structures of each ligand are also shown.
