Extended Data Fig. 7: Sequence comparison.
From: High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
a. Sequence alignment of the nsp14 N7-MTase domain from 7 pathogenic coronaviruses. The identical and similar residues are highlighted in dark gray and light gray, respectively. b. Sequence alignment of the nsp14 N7-MTase domain of SARS-CoV-2 and its variants. The secondary structure elements are shown above the sequence alignment. Red triangles highlight residues that interact with SAM. Blue circles highlight residues that coordinate the zinc ion.
