Extended Data Fig. 1: Global characteristics of study population.

a, Characteristics of the study cohort. P values were estimated via Wilcoxon rank sum test. b, Age distribution within the healthy (HG) and PD (PDG) cohort groups, separated by sex. Boxplots: median, center; first and third quantile, lower and upper hinges; largest/smallest value no further than 1.5 * inter-quantile range of the hinge, whiskers; data points beyond are defined as outliers and plotted individually. P values are indicated (Wilcoxon rank sum test, n = 51 subjects in HG, n = 52 subjects PDG). c, GO enrichment of all identified proteins in the CSF proteome (trypsin-only control data) using the human proteome (UniProt FASTA, July 2019) as the background. Only the 10 terms with the highest enrichment per GO domain are shown. Numerical data for graphs in b and c are available as source data.