Extended Data Fig. 2: Characterization of the binding between OspC3^ARD and caspase-4.

a, ITC profiles of caspase-4-p30-C/A binding to OspC3^ARD or OspC3 (WT or an indicated mutant). Data are representative of three independent experiments. b, Structural comparisons of OspC3^ARD and caspase-4-p30-C/A in the OspC3^ARD–caspase-4 complex with their cognate apo-states. c, d, Alignments of caspase sequences around the OspC3^ARD-binding region (c) and ARD sequences in different OspC3 homologues (d). Residues involved in OspC3^ARD–caspase-4 binding are highlighted in cyan. Identical residues are in red background and conserved residues are in red. Numbers of the starting residues are indicated on the left. Accession numbers of OspC3 homologues are the same as previously reported¹⁹.

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