Extended Data Fig. 3: EM-based visualization and quantification of R-loops on human genomic DNA upon estrogen-dependent transcriptional burst. | Nature Structural & Molecular Biology

Extended Data Fig. 3: EM-based visualization and quantification of R-loops on human genomic DNA upon estrogen-dependent transcriptional burst.

From: Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids

Extended Data Fig. 3: EM-based visualization and quantification of R-loops on human genomic DNA upon estrogen-dependent transcriptional burst.

a) Representative electron micrographs of R-loops found on genomic DNA from E2 stimulated cells. Scale bar: 200 bp/72 nm. b) Frequency of R-loops that are <300 bp in size in two independent biological replicates. Absolute numbers of R-loops <300 bp were normalized to the total DNA content within the analyzed area.

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