Fig. 4: A universal mechanism to control cohesin complexes.
a, Different chromosomal regulators control cohesin through a shared mechanism. CTCF through its YxF motif binds cohesin’s CES (gray circle) to stabilize CTCF-anchored loops21. SGO1 uses its YxF motif to bind cohesin’s CES to protect centromeric sister chromatid cohesion. Adapted with permission from ref. 2, Elsevier; ref. 21, Springer Nature Ltd. b, The SGO1–CES interaction dictates SGO1 localization along chromosomes until the establishment of microtubule–kinetochore attachments (S:SGO1).
