Extended Data Fig. 8: Comparison of catalytic and non-catalytic AtAgo10-guide-target structures.

a. Superposition of catalytic (central duplex) and non-catalytic (bent duplex) conformations. Arrow indicates the magnitude of movement traversed by the guide RNA 3’ end between conformations. b. Schematic of major contacts between AtAgo10 and the guide (red) and target (blue) RNAs in the non-catalytic (bent duplex) conformation. c. Schematic of major contacts between AtAgo10 and the RNAs in the catalytic (central duplex) conformation. Residues colored by domain, as in Fig. 1.