Extended Data Fig. 6: Ligand-induced local conformational changes in OCT1CS.
From: Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2
a, Structural overlay of apo-OCT1CS (marine), VPM-OCT1CS (green) and DPH-OCT1CS (yellow), showing that no large conformational changes are present among the three structures. While other residues remain relatively stable, Y36 exhibits considerable rotamer movement among the three structures.
