Extended Data Fig. 5: Quality control of neuronal genomics datasets.
From: Readout of histone methylation by Trim24 locally restricts chromatin opening by p53
(a) Reproducibility of p53 ChIPseq signal in the neuronal cells differentiated from the Trim24 degron line, in p53 active conditions, at all neuronal p53 peaks (n = 9535 sites). Shown are log2 enrichments over IgG control datasets for independent replicates (R1/R2). Pearson correlation coefficients are indicated. (b) Reproducibility of Trim24 ChIPseq signal in the neuronal cells differentiated from the Trim24 degron line, in p53 active conditions, at all neuronal Trim24 peaks (n = 2325 sites). Shown are log2 enrichments over IgG control datasets for independent replicates (R1/R2). Pearson correlation coefficients are indicated. (c) Reproducibility of ATACseq signal (log2 CPM) in the neuronal cells differentiated from the Trim24 degron line, in degraded, untreated and activated conditions with or without Trim24 degradation, for replicates (R1/R2) at all neuronal ATACseq peaks (n = 62070 sites). Pearson correlation coefficients are indicated. (d) Correlation-based clustering of ATACseq signal in the neuronal cells differentiated from the Trim24 degron line. Pearson correlations on log2 counts are as indicated.
